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Towards universal unfolding of detector effects in high-energy physics using denoising diffusion probabilistic models

Camila Pazos, Shuchin Aeron, Pierre-Hugues Beauchemin, Vincent Croft, Zhengyan Huan, Martin Klassen, Taritree Wongjirad

SciPost Phys. Core 8, 064 (2025) · published 2 October 2025

Abstract

Correcting for detector effects in experimental data, particularly through unfolding, is critical for enabling precision measurements in high-energy physics. However, traditional unfolding methods face challenges in scalability, flexibility, and dependence on simulations. We introduce a novel approach to multidimensional object-wise unfolding using conditional Denoising Diffusion Probabilistic Models (cDDPM). Our method utilizes the cDDPM for a non-iterative, flexible posterior sampling approach, incorporating distribution moments as conditioning information, which exhibits a strong inductive bias that allows it to generalize to unseen physics processes without explicitly assuming the underlying distribution. Our results highlight the potential of this method as a step towards a "universal" unfolding tool that reduces dependence on truth-level assumptions, while enabling the unfolding of a wide range of measured distributions with improved adaptability and accuracy.

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